Revolutionizing the Management of Polytrauma Patients
Introducing Watson Trauma Pathway Explorer©
a publication of the Swiss College of Surgeons
Introducing Watson Trauma Pathway Explorer©
A Swiss Surgeon's Experience in a Canadian Surgical and Transplant Oncology Research Centre
Hirschsprung`s disease is a multigenetic intestinal disorder characterized by a variable length of distal colonic aganglionosis. The exact cause is unknown but proposed pathological mechanisms are processes of the enteric neural crest-derived cell development and include faulty proliferation, insufficient cephocaudal migration, differentiation, and survival [1]. The consequences are continuous contraction and lack of peristalsis leading to functional intestinal obstruction at the terminal migratory site of ganglion cells [2]. Although Hirschsprung`s disease can affect any length from the internal anal sphincter to the entire large bowel the incidence is approximately 1 in 5000 births, with a male predominance of 4:1 in rectosigmoid Hirschsprung`s disease [3].
Damit diese Website ordnungsgemäß funktioniert und um dein Erlebnis zu verbessern, verwenden wir Cookies. Ausführlichere Informationen findest du in unserer Cookie-Richtlinie.
Notwendige Cookies ermöglichen die Kernfunktionen. Die Website kann ohne diese Cookies nicht richtig funktionieren und kann nur deaktiviert werden, indem du deine Browsereinstellungen änderst.